Transport properties of hydrophilic compounds in PLGA microspheres

Biodegradable polyesters, such as the poly(lactic-co-glycolic acid) (PLGA), have been extensively used a polymer matrix for entrapping variety of active compounds. In this study, physicochemical phenomena that control mass transport mechanism hydrophilic compounds released from PLGA microspheres were identified. This study aims to produce and characterize loaded with metformin hydrochloride (MH) perform case using literature data fluorescein isothiocyanate-dextran (FITC-dextran). The MH is low molecular weight compound was easily rapidly transported by diffusion through microsphere pores. FITC-dextran, high compound, depended on erosion mesopore formation, 18 days duration, before its release transfer. Values effective coefficient both in PLGA, 2.4 x 10-13 5.3 10-18 m2 s-1, respectively, difference five orders magnitude attributed these main governed their release. provides important insights into mechanisms transfer correlation properties matrix, contributing development biodegradable controlled delivery systems applications chemical, biotechnological, pharmaceutical industries.